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Shizune (シズネ) is the assistant of Tsunade and a talented medical ninja. She left Konoha with Tsunade after her uncle, Dan, died, and trained under Tsunade for many years afterwards. Shizune is quite close to Tsunade, being one of the few people Tsunade will trust with absolute certainty. Unlike Tsunade, she tends to stress over details like Tsunade's tendency to gamble and think with her heart. While she is deeply loyal to Tsunade, Shizune is more than willing to defy her wisdom if it is for the better good; in Part II she reports to Konoha's elders about some of Tsunade's decisions, causing interference with Tsunade's plans and creating a temporary strain between the two. Despite being a medical ninja, Shizune uses a number of poison-based jutsu in battle, such as spitting poisonous gas from her mouth or keeping concealed poisoned needles at the ready to use against others.
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